Impulse control disorders in patients with pituitary adenoma managed with or without dopamine agonists: a cross-sectional study from a UK centre
Authors' conclusion
In this sample of UK patients, prevalence of ICDs is higher in prolactinoma patients on DA compared to those with NFPA not on DA. Differences were not observed between patients with acromegaly treated or not with DA. Different ICD assessment tools have an impact on the detected outcomes.
Study context
- Population
- Adults with prolactinoma, acromegaly or non-functioning pituitary adenoma (NFPA) treated or not with dopamine agonist (DAs) in a UK pituitary centreanalysed
- Participants
- 200 adults
- Exposure
- Pituitary adenoma patients on DA vs not on DA
- Prolactinoma (on DA)n = 72
- NFPA (no DA)n = 71reference
- Acromegalyn = 57
- Outcome
- Prevalence of ICDs, screened with MIDI and QUIP-RS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Patients scoring for any ICD
| Outcome | Prolactinoma (on DA) | NFPA (no DA) | P value |
|---|---|---|---|
| MIDI | 12.7% | 1.4% | P = 0.02 |
| QUIP-RS | 46.5% | 18.6% | P < 0.001 |
Observational data: associations, not effects.
Further findings
DA use and ICD positivity
- DA use associated with positive scores for all impulse control disorders (ICDs) in Minnesota Impulse Disorders Interview (MIDI) and with compulsive buying and hobbyism-punding in QUIP-RS
- DA dose or treatment duration not associated with positive scores
Acromegaly on DA vs not on DA
- Responses of acromegaly patients on DA did not differ from those not on DA in any questionnaire
Original publication
Impulse control disorders in patients with pituitary adenoma managed with or without dopamine agonists: a cross-sectional study from a UK centre. Pituitary. Published 21 April 2025. doi:10.
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