Computed Tomography Cardiac Angiography Findings in Patients With Sheehan Syndrome
Authors' conclusion
Approximately one-fourth of patients with SS were found to have atherosclerotic plaques in their coronary arteries, highlighting their increased susceptibility to CV morbidity and mortality.
Study context
- Population
- Women with Sheehan syndrome on standard replacement therapy incl. thyroxine and glucocorticoids; mean age 54.20 ± 8.27 years, mean pituitary disease duration 22.67 ± 6.27 years
- Participants
- 30 women
- Outcome
- Presence of coronary artery plaques on CT cardiac angiography
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Coronary artery plaques on CT cardiac angiography
Coronary artery plaques
23.3%
n = 7
Noncalcified plaques
4 patients
Calcified plaques
2 patients
Both calcified and noncalcified plaques
1 patient
Observational data: associations, not effects.
Further findings
Coronary artery calcium (CAC) score risk stratification for coronary artery disease
- Minimal risk (CAC 1-10)
- 6.7% (n = 2)
- Mild risk (CAC 11-100)
- 16.7% (n = 5)
- Moderate risk (CAC 101-400)
- 3.3% (n = 1)
Correlation between CAC scores and % stenosis
- Strong positive correlation, r
- 0.96, P = .01
Original publication
Computed Tomography Cardiac Angiography Findings in Patients With Sheehan Syndrome. Endocr Pract. Published 15 April 2025. doi:10.
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