Bone mineral density, turnover, and microarchitecture assessed by second-generation high-resolution peripheral quantitative computed tomography in patients with Sheehan’s syndrome
Authors' conclusion
Low areal BMD (aBMD) is highly prevalent in SS as compared to age- and BMI-matched controls. However, there were no significant differences in bone microarchitectural measurements, except for tibial cortical vBMD, which was lower in adequately treated SS patients.
Study context
- Population
- Patients with Sheehan's syndrome on stable hormone replacement; mean age 45.5 ± 9.3 years; glucocorticoid 94%, LT4 94%, estrogen-progestin 58%; none had prior growth hormone (GH) replacement
- Participants
- 35 vs 35
- Comparison
- Sheehan's syndrome (SS) patients vs age- and BMI-matched controls
- SSn = 35
- Controlsn = 35reference
- Outcome
- Osteoporosis and osteopenia (DXA areal BMD (aBMD))
Methodological detailsage- and BMI-matched controls
- Age- and BMI-matched controls
Main finding
As reported in the abstract
- Osteoporosis and osteopenia at lumbar spine and femoral neck present in greater proportion in SS than matched controls
- SS vs Controls: P = 0.01
- SS vs Controls: P = 0.007
- SS vs Controls: P = 0.001
- SS vs Controls: P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Bone microarchitecture (HR-pQCT)Lower with SS | P = 0.02 |
Bone turnover markers (BTMs) (P1NP and CTX)
- Not significantly different between SS and controls
Bone microarchitecture (HR-pQCT)
- Relative preservation of the other microarchitecture parameters
Original publication
Bone mineral density, turnover, and microarchitecture assessed by second-generation high-resolution peripheral quantitative computed tomography in patients with Sheehan’s syndrome. Osteoporos Int. Published 20 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →