Opportunistic Evaluation of Trabecular Bone Texture by Magnetic Resonance Imaging (MRI) Reflects Bone Mineral Density and Microarchitecture
Authors' conclusion
MRI-based measurements of trabecular bone texture relate to vBMD and microarchitecture, suggesting that this method reflects underlying microstructural properties of trabecular bone. Further investigation is required to validate this methodology, which could greatly improve identification of patients with skeletal fragility.
Study context
- Population
- Patients (mean age 64, 54% women) with spine volumetric bone mineral density (vBMD) by quantitative computed tomography (QCT), peripheral vBMD and microarchitecture by high-resolution peripheral QCT (HRpQCT), areal BMD (aBMD) by DXA, and vertebral T1-weighted MRI
- Participants
- 46 patients
- Outcome
- Associations of MRI trabecular bone texture features (contrast, entropy, ASM, IDM) with vBMD and microarchitecture
Main finding
As reported in the abstract
Lower peripheral vBMD and worse trabecular microarchitecture by HRpQCT associated with higher contrast and entropy
r ∼ −0.3 to 0.4
P < .05
Lower peripheral vBMD and worse trabecular microarchitecture by HRpQCT associated with lower angular second moment (ASM) and inverse difference moment (IDM)
r ∼ +0.3 to 0.4
P < .05
Lower spine vBMD by QCT associated with higher contrast and entropy
r ∼ −0.5
P < .001
Lower spine vBMD by QCT associated with lower ASM and IDM
r ∼ +0.5
P < .001
Observational data: associations, not effects.
Original publication
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