Association between vertebral fracture risk and bone mineral density in patients with acromegaly
Authors' conclusion
Vertebral fractures are common in acromegaly. In one of the largest Chinese acromegaly cohorts to date, QCT demonstrated superior discrimination of VF risk compared with DXA, supporting its potential complementary role in skeletal fragility assessment in acromegaly.
Study context
- Population
- Patients with acromegaly
- Participants
- 149 patients
- Exposure
- Patients with vertebral fractures (VFs) vs without VFs; Quantitative computed tomography (QCT) vs DXA for bone mineral density (BMD) assessment
- Outcome
- Prevalence and risk factors of VFs; comparison of BMD by DXA and QCT
Main finding
As reported in the abstract
Prevalence of VFs
VF prevalence
39.6%
Observational data: associations, not effects.
Further findings
BMD by QCT and DXA in patients with vs without VFs
- QCT-derived volumetric BMD (vBMD) significantly lower in patients with VFs
- DXA lumbar areal BMD (aBMD) did not differ between groups
Original publication
Association between vertebral fracture risk and bone mineral density in patients with acromegaly. Pituitary. Published 9 December 2025. doi:10.
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