Trabecular bone mineral density as measured by thoracic vertebrae predicts incident hip and vertebral fractures: the multi-ethnic study of atherosclerosis
Main finding · First hip fractureResult — go to the resultHazard ratio 1.57 95% CI 1.38–1.95Authors' conclusion
There is significant correlation between thoracic trabecular BMD and the incidence of future hip and vertebral fracture.
Study context
- Population
- Multi-Ethnic Study of Atherosclerosis (MESA) baseline participants from six medical centres across the USA (mean age 62.2 ± 10.2 years; 52.8% women)
- Participants
- 6,814 participants
- Exposure
- Low vs normal thoracic trabecular bone mineral density (BMD) by QCT on non-contrast cardiac computed tomography (CT)
- Outcome
- Incident hip and vertebral fractures
- Follow-up
- Median 17.4 years
Methodological detailsmulticentre, multi-ethnic
- Multicentre
- Multi-ethnic
Main finding
First hip fracture
Hazard ratio
1.57
95% CI 1.38–1.95
Low BMDvs Normal BMD
HR 1.57 (95% CI 1.38–1.95)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| First vertebral fracture · median follow-up 17.4 years | 2.93 (1.87–4.59) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Difference (mg/cm³) | P value |
|---|---|---|
| Baseline vBMD, hip fracture vs no hip fractureLower in hip fracture patients | 13.6 | P < 0.001 |
| Mean BMD, vertebral fracture vs no vertebral fractureLower in vertebral fracture population | 18.3 | P < 0.001 |
Mean thoracic BMD and osteoporosis prevalence at baseline
- Mean thoracic BMD (mg/cm³)
- 162.6 ± 46.8 (95% CI 161.5, 163.7)
- Osteoporosis (T-score 2.5 or lower)
- 27.6% (n = 1883)
Vertebral fracture rate by race · median follow-up 17.4 years
- Caucasians
- 6.9%
- Blacks
- 4.4%
- Hispanics
- 3.7%
- Chinese
- 3.0%
Original publication
Trabecular bone mineral density as measured by thoracic vertebrae predicts incident hip and vertebral fractures: the multi-ethnic study of atherosclerosis. Osteoporos Int. Published 22 March 2024. doi:10.
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