Conventional chest computed tomography-based radiomics for predicting the risk of thoracolumbar osteoporotic vertebral fractures
Authors' conclusion
Radiomics analysis based on conventional chest CT can provide valuable information for predicting thoracolumbar OVFs.
Study context
- Population
- Patients who underwent conventional chest CT, including patients with thoracolumbar osteoporotic vertebral fractures198 with thoracolumbar osteoporotic vertebral fractures (OVFs)
- Participants
- 494 patients
- Comparison
- Chest CT radiomics models (trabecular, cortical-appendicular, mixed radiomics features (RFs), RAD score) vs lumbar bone mineral density (BMD) for predicting thoracolumbar OVFs
- Outcome
- Prediction of thoracolumbar OVFs, evaluated by AUC
Methodological detailsretrospective, training and validation sets, radiomics, Training set 1 (n = 334) and validation set 1 (n = 160)
- Retrospective
- Training and validation sets
- Radiomics
- Training set 1 (n = 334) and validation set 1 (n = 160)
Performance
As reported in the abstract
AUC for predicting thoracolumbar OVFs, RAD score models by vertebral combination
| Test or model | AUC |
|---|---|
| RAD score top 3 (T5 + T8 + T10) | 0.813 |
| RAD score T7-T12 | 0.780 |
| RAD score T1-T6 | 0.772 |
AUC
RAD score top 3 (T5 + T8 + T10)0.813
RAD score T7-T120.780
RAD score T1-T60.772
- RAD score top 3 (T5 + T8 + T10) vs RAD score T7-T12: P = 0.02
- RAD score top 3 (T5 + T8 + T10) vs RAD score T1-T6: P = 0.062
Further findings
| Outcome | BMD | P value |
|---|---|---|
| AUC vs lumbar BMD, before age adjustmentSlightly superior, not statistically significant | P > 0.05 | |
| AUC | 0.736 | |
| AUC vs lumbar BMD, after age adjustmentComparable | P > 0.05 | |
| AUC | 0.785 |
- AUC vs lumbar BMD, before age adjustment: RAD score models AUC 0.774-0.807
- AUC vs lumbar BMD, before age adjustment: RAD score + BMD models AUC 0.771-0.800
- AUC vs lumbar BMD, before age adjustment: subset with BMD data: training set 2 n = 199, validation set 2 n = 88
- AUC vs lumbar BMD, after age adjustment: RAD score models AUC 0.784-0.804
Original publication
Conventional chest computed tomography-based radiomics for predicting the risk of thoracolumbar osteoporotic vertebral fractures. Osteoporos Int. Published 27 March 2025. doi:10.
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