Cervicothoracic volumetric bone mineral density assessed by opportunistic quantitative computed tomography (QCT) may be a reliable marker for osteoporosis in adults
Authors' conclusion
Cervicothoracic vBMD may allow for determination of osteoporosis and prediction of VFs.
Study context
- Population
- Patients with routine non-contrast or contrast-enhanced multi-detector CT (MDCT) scans (65.3 ± 19.2 years, 140 women)140 women
- Participants
- 325 patients
- Comparison
- Cervical and thoracic volumetric bone mineral density (vBMD) vs lumbar vBMD for discriminating osteoporosis and prevalent vertebral fractures (VFs)
- Outcome
- Discrimination of osteoporosis (lumbar vBMD < 80 mg/cm³) by cervicothoracic vBMD
Methodological detailsopportunistic QCT, convolutional neural network (CNN)-based automated vBMD extraction, lumbar vBMD as reference
- Opportunistic QCT
- CNN-based automated vBMD extraction
- Lumbar vBMD as reference
Performance
As reported in the abstract
Discrimination of osteoporosis (vBMD < 80 mg/cm³)
| Test or model | AUC | AUC excluding degenerated vertebrae |
|---|---|---|
| Cervical vBMD | 0.94 | 0.97 |
| Thoracic vBMD | 0.97 | — not stated in the abstract |
AUC
Cervical vBMD0.94
Thoracic vBMD0.97
AUC excluding degenerated vertebrae
Cervical vBMD0.97
Thoracic vBMD— not stated in the abstract
— not stated in the abstract
Further findings
| Outcome | Cervical vBMD | Thoracic vBMD | Lumbar vBMD |
|---|---|---|---|
| Discrimination of patients with vs without prevalent VFs | |||
| AUC | 0.74 | 0.72 | 0.72 |
| Proposed vBMD cut-offs indicating osteoporosis | < 190 mg/cm³ | < 100 mg/cm³ | < 80 mg/cm³ |
Correlation of cervicothoracic with lumbar vBMD
- Correlation, all vertebrae
- r = 0.79
- Correlation after excluding degenerated vertebrae (except C7-T3 and T9)
- r = 0.89
- Significant improvement after excluding degenerated vertebrae (p < 0.05)
Original publication
Cervicothoracic volumetric bone mineral density assessed by opportunistic QCT may be a reliable marker for osteoporosis in adults. Osteoporos Int. Published 31 December 2024. doi:10.
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