Individuals with heterogenous trabecular bone texture by clinical magnetic resonance imaging have lower bone strength and stiffness by quantitative computed tomography-based finite element analysis
Authors' conclusion
In summary, individuals with more heterogeneous MRI-based trabecular texture had lower stiffness and failure load by FEA, and lower vBMD by central quantitative CT.
Study context
- Population
- Individuals with CT and MRI of L1 and L2 vertebrae; mean age 59 ± 11 yr, 57% female
- Participants
- 30 individuals
- Outcome
- Relationships between MRI-based texture features (contrast, entropy, ASM, IDM) and whole-bone stiffness and failure load by QCT-based finite element analysis
Main finding
As reported in the abstract
Vertebral stiffness vs MRI texture features
Lower stiffness with greater texture heterogeneity: contrast, correlation r
−0.54
p < .01
Entropy, correlation r
−0.52
p < .01
Inverse difference moment (IDM), correlation r
0.54
p < .01
Angular second moment (ASM), correlation r
0.51
p < .01
Observational data: associations, not effects.
Further findings
Vertebral failure load and vBMD vs texture
- Lower vertebral failure load and lower vBMD similarly associated with greater texture heterogeneity
Texture direction
- Relationships unchanged using the average of all directions or the vertical direction alone
Original publication
Individuals with heterogenous trabecular bone texture by clinical magnetic resonance imaging have lower bone strength and stiffness by quantitative computed tomography-based finite element analysis. J Bone Miner Res. Published 28 December 2024. doi:10.
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