Prevalence of Vitamin D Deficiency With Biochemical Abnormalities in Children Undergoing Vitamin D Testing
Authors' conclusion
VDDba is uncommon in children undergoing 25OHD testing, and occurs almost entirely in children < 3 years.
Study context
- Population
- Children (<18 years) with 25OHD measurements and ≥2 of aCa, parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months, regional laboratory, 1 January 2009 to 15 June 2020; mean age 8 y, 47% female12,858 25OHD measurements
- Participants
- 9,516 children
- Outcome
- Prevalence of vitamin D deficiency with biochemical abnormalities (VDDba: low aCa, elevated PTH and elevated ALP) and the 25OHD concentrations at which it arises
Methodological detailsregional laboratory database, clinical record review with consensus diagnosis
- Regional laboratory database
- Clinical record review with consensus diagnosis
Main finding
As reported in the abstract
Clinically confirmed VDDba
- Proportion of clinically confirmed VDD with biochemical abnormalities (VDDba), all eligible 25OHD measurements
- 0.9%
- Proportion of clinically confirmed VDDba, 25OHD <25 nmol/L
- 8%
- Individuals with clinically confirmed VDDba episodes
- 118 individuals (111 <3 years), 120 episodes
- Episodes: clinical rickets / biochemical rickets / hypocalcaemia / secondary hyperparathyroidism / partially treated rickets
- 62 / 15 / 16 / 23 / 4
- Undetectable 25OHD among VDDba
- 56
- 25OHD <25 nmol/L among VDDba
- 104
Observational data: associations, not effects.
Further findings
25OHD distribution
- Median 25OHD
- 61 nmol/L
- 25OHD <50 nmol/L
- 36%
- 25OHD <25 nmol/L
- 10%
Index 25OHD measurements categorised as VDDba (laboratory criteria)
- Total
- 152
- Confirmed / possible / potential
- 30 / 23 / 99
Original publication
Prevalence of Vitamin D Deficiency With Biochemical Abnormalities in Children Undergoing Vitamin D Testing. Clin Endocrinol (Oxf). Published 27 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →