The Challenge of Fractures in Patients With Chronic Kidney Disease
Authors' conclusion
Current data are limited on efficacy and safety of treatments for fracture prevention in CKD. As new medications for the treatment of osteoporosis become available, there is an urgency to establish more clear guidelines for the diagnosis, fracture risk stratification, and treatment of bone disease in CKD.
Study context
- Population
- People with chronic kidney disease (CKD); studies on pathophysiology of CKD mineral bone disorder, fracture risk assessment and therapeutic options in CKD
Methodological detailsLiterature review of PubMed
- Literature review of PubMed
Main finding
As reported in the abstract
- Higher fracture risk in CKD relates to interplay of changes in bone turnover (T), mineralization (M) and volume (V), plus other risk factors accumulated as GFR declines
- Diagnosis of renal osteodystrophy type is not based only on bone density and traditional osteoporosis risk factors
- Currently available fracture risk tools have limitations in CKD
- Treatment choice should consider the 3 TMV components, CKD stage and comorbidities, but assessment of these components is not well established
Original publication
The Challenge of Fractures in Patients With Chronic Kidney Disease. Endocr Pract. Published 27 December 2024. doi:10.
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