The role of sympathetic control in bone vasculature: insights from spinal cord injury
Authors' conclusion
Our findings indicate that in the absence of sympathetic mechanisms, myogenic control may play a compensatory role in regulating blood flow, though to a lesser extent in bone compared to muscle. The close relationship between lesser declines in bone blood content and higher BMD underscores the link between blood flow and bone health.
Study context
- Population
- Individuals with spinal cord injury and controls; tibial vascular responses to isometric handgrip exercise (IHE) sustained to fatigue
- Participants
- 12 vs 12
- Comparison
- Individuals with spinal cord injury vs controls
- Spinal cord injury (SCI)n = 12
- Controlsn = 12reference
- Outcome
- Vascular responses to IHE (whole leg VR; tibial hemoglobin via near-infrared spectroscopy)
- Follow-up
- During IHE
Main finding
As reported in the abstract
- Controls showed active sympathetic vasoconstriction in whole leg (increased VR) and tibia (decreased hemoglobin)
- SCI showed modest whole leg vasoconstriction with lesser VR increases than controls
- SCI tibial hemoglobin increased until plateauing at higher pressure levels
- SCI vs Controls: P < 0.04
- SCI vs Controls: P < 0.01
Further findings
Relationship between leg BMD (DXA) and tibial hemoglobin at end of IHE, SCI subgroup
- r2
- 0.67, p < .01
- Subgroup of 9 individuals with SCI
Original publication
The role of sympathetic control in bone vasculature: insights from spinal cord injury. J Bone Miner Res. Published 23 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →