Change in bone mineral density after parathyroidectomy for secondary hyperparathyroidism: a review
Authors' conclusion
PTx consistently improves BMD in patients with refractory secondary hyperparathyroidism, with the greatest gains at cancellous-rich skeletal sites.
Study context
- Population
- Adults with secondary hyperparathyroidism due to CKD with DXA-measured bone mineral density (BMD) before and after PTx
- Participants
- 452 adults11 studies
- Comparison
- BMD before vs after parathyroidectomy
- Outcome
- Change in DXA-measured BMD after PTx
Methodological detailsSearched PubMed, Embase and Scopus from inception through January 2026; two reviewers independently screened and selected studies (PICOS)
- Searched PubMed, Embase and Scopus from inception through January 2026; two reviewers independently screened and selected studies (PICOS)
Pooled result
As reported in the abstract
BMD change after PTx
Lumbar spine BMD gain
+7-50% g/cm²
Femoral neck BMD gain
+8-23% g/cm²
Further pooled results
Predictors of skeletal recovery
- Higher preoperative PTH, elevated alkaline phosphatase and lower baseline BMD associated with greater skeletal recovery
PTx vs cinacalcet (single RCT)
- The only available RCT confirmed superiority of PTx over cinacalcet for BMD improvement
Original publication
Change in bone mineral density after parathyroidectomy for secondary hyperparathyroidism: a review. J Clin Endocrinol Metab. Published 3 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →