Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia
Authors' conclusion
Parathyroidectomy significantly improved BMD and remodeling biomarkers in women with osteopenia, thereby supporting the benefit of parathyroidectomy in these patients. Preoperative serum CTX and P1NP concentrations could be useful to predict expected BMD gain.
Study context
- Population
- Women operated for sporadic primary hyperparathyroidism (PHPT) since 2016 with ≥1 year follow-up (CoHPT cohort); 62.5 ± 13.3 years, 83.1% menopausal, 43.9% osteopenic, 45.1% osteoporotic
- Participants
- 177 women
- Exposure
- Bone mineral density (BMD) before vs 1 year after parathyroidectomy
- Osteopenian = 72
- Outcome
- BMD change between before and after parathyroidectomy
- Follow-up
- 1 year
Methodological detailsmonocentric, observational, referral center
- Monocentric
- Observational
- Referral center
Main finding
As reported in the abstract
Mean BMD change in patients with baseline osteopenia · 1 year after parathyroidectomy
Lumbar spine, g/cm²
+0.05
95% CI 0.03–0.07
Femoral neck, g/cm²
+0.02
95% CI 0.00–0.04
Total hip, g/cm²
+0.02
95% CI 0.01–0.02
Forearm
+0.01
95% CI 0.00–0.02
Observational data: associations, not effects.
Further findings
Preoperative predictors of BMD gain (>0.03 g/cm² at ≥1 site) in osteopenic patients
- Higher preoperative serum CTX, P1NP and urine calcium in those with BMD gain vs without improvement
Original publication
Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia. J Clin Endocrinol Metab. Published 28 December 2023. doi:10.
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