Utility of MRI-based vertebral bone quality scores and CT-based Hounsfield unit values in vertebral bone mineral density assessment for patients with diffuse idiopathic skeletal hyperostosis
Authors' conclusion
DXA-based T-scores may overestimate BMD in DISH.
Study context
- Population
- Patients with diffuse idiopathic skeletal hyperostosis and age-matched controls with lumbar spinal stenosis
- Participants
- 105 vs 116
- Comparison
- Diffuse idiopathic skeletal hyperostosis (DISH) vs age-matched controls with lumbar spinal stenosis; DXA T-scores, MRI-based vertebral bone quality (VBQ) scores and CT-based Hounsfield unit (HU) values
- DISHn = 105
- Controlsn = 116reference
- Outcome
- Diagnostic effectiveness of DXA, MRI and CT in assessing BMD; prevalence of normal BMD by T-score, VBQ and HU
Methodological detailsage-matched controls, ROC analysis
- Age-matched controls
- ROC analysis
Performance
As reported in the abstract
Normal BMD prevalence
Normal bone mineral density (BMD) prevalence by DXA T-scores
69.5% vs. 58.6%
P < 0.05
DISH
Normal BMD prevalence by VBQ
57.1% vs. 56.2%
P > 0.05
DISH
Normal BMD prevalence by HU
58.1% vs. 57.8%
P > 0.05
DISH
Further findings
| Outcome | DISH | Controls |
|---|---|---|
| Correlation of HU with T-scores (L1-4)Moderate in DISH, strong in controls | ||
| R | 0.642 | 0.846 |
| P | P < 0.001 | P < 0.001 |
| Correlation of VBQ with T-scores (L1-4)Moderate negative in DISH, strong in controls | ||
| R | - 0.450 | - 0.813 |
| P | P < 0.001 | P < 0.001 |
- Diagnosis of normal BMD (DXA reference) in controls
- 0.857 · AUC VBQ · AUC HU 0.910 · VBQ cutoff 3.0 · HU cutoff 104.3
Original publication
Utility of MRI-based vertebral bone quality scores and CT-based Hounsfield unit values in vertebral bone mineral density assessment for patients with diffuse idiopathic skeletal hyperostosis. Osteoporos Int. Published 27 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →