Bone microarchitecture and mechanical competence are associated with fracture across race and sex in older adults
Authors' conclusion
In conclusion, in this multiethnic cohort, stiffness and FL were independently associated with prevalent and incident fractures, regardless of race or sex.
Study context
- Population
- Older adults in New York City; age 76.1±6.3 yrs, 71% female, 27.7% Black, 29.7% White, 41.3% Mixed32% had 444 fractures
- Participants
- 935 adults
- Exposure
- Historical fracture vs no fracture
- Outcome
- Failure load (FL) and stiffness by fracture status
Methodological detailshigh-resolution peripheral quantitative CT, microfinite element analysis, multiethnic
- High-resolution peripheral quantitative CT
- Microfinite element analysis
- Multiethnic
Main finding
As reported in the abstract
Distal radius: Fx group had worse trabecular (Tb) and cortical (Ct) parameters with lower failure load (FL) and stiffness (p<0.001)
9.7-10.3%
Distal tibia: lower FL and stiffness in Fx group (p<0.001)
5.9%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Incident fracture per higher stiffness and FL (whole cohort)Higher radius stiffness | 0.732 (0.563–0.931) | P = 0.014 | |
| Incident fracture per higher stiffness and FL (whole cohort)Higher tibia stiffness | 0.866 (0.783–0.954) | P = 0.004 | |
| Incident fracture per higher stiffness and FL (whole cohort)Higher radius FL | 0.597 (0.404–0.893) | P = 0.011 | |
| Incident fracture per higher stiffness and FL (whole cohort)Higher tibia FL | 0.778 (0.681–0.888) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Incident fracture by Hispanic ethnicity
| OR (95% CI) | P value | ||
|---|---|---|---|
| HispanicIndependent of radial stiffness | 0.289 (0.081–0.845) | P = 0.038 | |
| HispanicIndependent of radial FL | 0.286 (0.080–0.842) | P = 0.038 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Bone microarchitecture and mechanical competence are associated with fracture across race and sex in older adults. J Bone Miner Res. Published 31 July 2026. doi:10.
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