Cost-effectiveness of FRAX®-based intervention thresholds for management of osteoporosis in Indian women: a Markov microsimulation model analysis
Authors' conclusion
The results support the integration of FRAX®-based fixed ITs from the age of 50 years and age-based ones from the age of 65 years in India to optimize resource allocation and improve osteoporosis management.
Study context
- Population
- Indian women over 50 years
- Comparison
- FRAX®-based intervention thresholds for treatment with generic alendronate
- Outcome
- Costs, QALYs and ICER of FRAX®-based intervention thresholds with generic alendronate
Methodological detailsMarkov microsimulation model, adapted to the Indian healthcare context, cost-effectiveness threshold: one-time gross domestic product (GDP) per capita, full and real-world adherence scenarios, Limitations: reliance on fracture incidence data from Singaporean Indians and variability in fracture prevalence across India
- Markov microsimulation model
- Adapted to the Indian healthcare context
- Cost-effectiveness threshold: one-time GDP per capita
- Full and real-world adherence scenarios
- Limitations: reliance on fracture incidence data from Singaporean Indians and variability in fracture prevalence across India
Main finding
As reported in the abstract
Cost-effectiveness of generic alendronate by FRAX® intervention threshold
Major osteoporotic fracture (MOF) intervention thresholds (ITs) from age 60, full adherence: ICER (INR per QALY gained)
102,151
MOF ITs from age 65, real-world adherence: ICER (INR per QALY gained)
28,203
Hip fracture (HF) ITs at age 60: ICER (INR)
67,144
Original publication
Cost-effectiveness of FRAX®-based intervention thresholds for management of osteoporosis in Indian women: a Markov microsimulation model analysis. Osteoporos Int. Published 27 December 2024. doi:10.
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