Parathyroid Cystic Adenoma: A Systematic Review and Meta-Analysis
Pooled result · PCA detection rateResult — go to the resultOdds ratio 3.589Authors' conclusion
Although US and 4D-CT showed a significantly high rate in diagnosing PCA, (99m)Tc-SPECT showed a lower PCA diagnostic rate. These findings suggest that larger cystic lesions suspected as PCAs should be further evaluated using 4D-CT rather than (99m)Tc-SPECT.
Study context
- Population
- Patients with parathyroid cystic adenoma (parathyroid cystic adenomas (PCA)) in English articles published 1995–2020 (PubMed, Cochrane); 68% female, mean age 53.9 years
- Participants
- 160 patients39 studies
- Comparison
- Imaging modalities for localising parathyroid cystic adenoma
- Outcome
- PCA detection (diagnostic) rate by imaging modality
Pooled result
PCA detection rate
Odds ratio
3.589
P < 0.001
By group
As reported in the abstract
- (99m)Tc-SPECT diagnostic rate significantly lower than ultrasound (US)-guided FNA, computed tomography (CT) combined with 4D-CT, and combined US, CT, 4D-CT and MRI
- P < 0.001
Further pooled results
Patient and lesion characteristics
- Single cystic adenoma
- 98.1%
- Mean calcium corrected for albumin
- 12.6 ± 2.7 mg/dL
- Mean PTH
- 565.5 ± 523.8 pg/mL
- Mean PCA size by US
- 4.8 ± 3.6 cm
- Mean PCA size by CT
- 5.2 ± 3.2 cm
- Mean PCA size ex vivo
- 3.5 cm
- Median weight
- 8.1 g
Original publication
Parathyroid Cystic Adenoma: A Systematic Review and Meta-Analysis. Endocr Pract. Published 10 November 2022. doi:10.
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