Evaluating Fluorine-18–Fluorocholine Positron Emission Tomography/Computed Tomography as a First-Line Imaging Modality for Localizing Parathyroid Adenomas in Clinical Practice: Benefits and Challenges
Authors' conclusion
FCH-PET/CT yields a high diagnostic performance in clinical practice, thus making it one of the reliable first-line imaging procedures. Despite several benefits, the procedure holds challenges with regard to hyperplasia detection and intrathyroidally located adenomas. These observations from an early adopting center should be in consideration for other sites, looking to implement FCH-PET/CT as a first-line imaging procedure in clinical practice.
Study context
- Population
- Patients referred for hyperparathyroidism imaging39 underwent parathyroidectomy
- Participants
- 58 patients
- Outcome
- Diagnostic performance of FCH-PET/CT vs histopathology (per-patient and per-lesion) and 6-month biochemical follow-up
Methodological detailsreal-world setting, first-line imaging
- Real-world setting
- First-line imaging
Performance
As reported in the abstract
Per-patient sensitivity
97.4%
Per-patient PPV
100%
Per-lesion sensitivity
82.6%
Per-lesion PPV
97.4%
Further findings
Radiation burden and acquisition time vs previous imaging procedure
- Reduction in radiation burden
- 43%
- Reduction in acquisition time
- 82%
Challenges
- Histopathology revealed superiority in detecting adenomas over hyperplasia
- Detecting intrathyroidal adenomas and hyperplasia was challenging
Original publication
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