Comparison of 4D computed tomography and F‐18 fluorocholine PET for localisation of parathyroid lesions in primary hyperparathyroidism: A systematic review and meta‐analysis
Authors' conclusion
Both 4DCT and FCH PET/CT scan performed well in newly diagnosed patients, patients with persistent disease and in those with inconclusive conventional imaging results. FCH PET/CT scan had a higher pooled sensitivity than 4DCT in detecting patients with PHPT in head to head comparison.
Study context
- Population
- Patients with primary hyperparathyroidism (PHPT); studies from PubMed and EMBASE using histology as gold standard46 studies
- Participants
- 952 vs 1,651
- Comparison
- FCH PET/CT vs 4DCT for quadrant-wise localisation of parathyroid lesions
- FCH PET/CTn = 952
- 4DCTn = 1,651reference
- Outcome
- Diagnostic performance (pooled sensitivity) for quadrant-wise localisation
Methodological detailshead-to-head comparison, histology as gold standard, PubMed and EMBASE searched
- Head-to-head comparison
- Histology as gold standard
- PubMed and EMBASE searched
Pooled result
As reported in the abstract
Pooled sensitivity, per patient analysis
| Group | Value | Sensitivity |
|---|---|---|
| FCH PET/CT | 92% (CI 88–94) | 92% |
| 4DCT | 85% (CI 73–92) | 85% |
Value
FCH PET/CT92% (CI 88–94)
4DCT85% (CI 73–92)
Sensitivity
FCH PET/CT92%
4DCT85%
Further pooled results
Pooled sensitivity, per lesion analysis
Sensitivity
Sensitivity in subgroup with negative conventional imaging/persistent PHPT
Sensitivity
| Outcome | FCH PET/CT | 4DCT | OR (CI) | P value |
|---|---|---|---|---|
| Detection rate, per patient, head-to-head subpopulation (both modalities reported)Better detection with FCH PET/CT | 92.4 | 76.85 | −3.89 (1.6–9.36) | P = 0.0024 |
Sensitivity in subgroup with negative conventional imaging/persistent PHPT
- FCH PET/CT had comparable sensitivity to 4DCT
Original publication
Comparison of 4D computed tomography and F‐18 fluorocholine PET for localisation of parathyroid lesions in primary hyperparathyroidism: A systematic review and meta‐analysis. Clin Endocrinol (Oxf). Published 8 January 2023. doi:10.
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