Localization of Ectopic Hyperparathyroidism: Ultrasound Versus 99mTc-sestamibi, 4-Dimensional Computed Tomography, and 11C-choline Positron Emission Tomography/Computed Tomography
Authors' conclusion
US is a valuable tool for the localization of ectopic hyperparathyroidism, especially for ectopic lesions in the neck region.
Study context
- Population
- Patients with ectopic hyperparathyroidism among 527 patients with surgically confirmed primary hyperparathyroidism
- Participants
- 79 patients83 ectopic lesions
- Comparison
- US vs 99mTc-MIBI, US + MIBI, 4D-CT and 11C-choline PET/CT for localization of ectopic hyperparathyroidism
- Outcome
- Sensitivity for localization of ectopic parathyroid lesions
Performance
As reported in the abstract
| Test or model | Sensitivity |
|---|---|
| US | 75.9% |
| 99mTc-MIBI | 81.7% |
| US + MIBI | 95.1% |
| 4D-CT | 83.3% |
| 11C-choline PET/CT | 100% |
Sensitivity
US75.9%
99mTc-MIBI81.7%
US + MIBI95.1%
4D-CT83.3%
11C-choline PET/CT100%
- Between US and 99mTc-MIBI, US + MIBI, 4D-CT, 11C-choline PET/CT: P > 0.05 — not statistically significant
Further findings
US sensitivity: neck region vs anterior mediastinum/chest wall lesions
- US sensitivity significantly higher for neck than anterior mediastinum/chest wall lesions
- 85.9% vs. 42.1%, P < .001
99mTc-MIBI and 4D-CT sensitivity: neck vs anterior mediastinum/chest wall lesions
- 99mTc-MIBI sensitivity not significantly different between the two locations
- 84.1% vs. 94.6%, P = .193
- 4D-CT sensitivity not significantly different between the two locations
- 81.3% vs. 85.7%, P = 1
11C-choline PET/CT sensitivity by location
- 11C-choline PET/CT sensitivity in both neck and anterior mediastinum/chest wall lesions
- 100%
Original publication
Localization of Ectopic Hyperparathyroidism: Ultrasound Versus 99mTc-sestamibi, 4-Dimensional Computed Tomography, and 11C-choline Positron Emission Tomography/Computed Tomography. Endocr Pract. Published 18 December 2023. doi:10.
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