Ambulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture
Authors' conclusion
These differences in tibial metaphysis size and trabecular microarchitecture are similar to those observed in disuse and thus could be a result of abnormal biomechanics or low levels of physical activity.
Study context
- Population
- Ambulatory children aged 3–8 years with spastic cerebral palsy (CP) (spasticity in both lower limbs)High resolution peripheral quantitative computed tomography (HR-pQCT) subset n = 5
- Participants
- 12 vs 7
- Exposure
- Ambulatory children with spastic CP vs normative data (DXA) and healthy children (HR-pQCT)
- CPn = 12
- Healthy childrenn = 7reference
- Outcome
- DXA aBMD Z-score at proximal femur
Main finding
As reported in the abstract
CP
−1.8
median · IQR −2.2–-1.2
P = 0.03
Observational data: associations, not effects.
Further findings
Correlations of gait pathology and energy expenditure index with DXA-based bone outcomes
- Gait pathology vs DXA-based bone outcomes, correlation coefficient
- 0.62 [p = .04] to 0.73 [p = .01]
- Energy expenditure index vs DXA-based bone outcomes, correlation coefficient
- −0.63 [p = .03] to −0.98 [p ≤ .001]
HR-pQCT bone geometry and trabecular microarchitecture at metaphyseal tibia
- Total area lower in CP than controls
- 35%
- Trabecular area lower in CP than controls
- 42%
- Trabecular number lower in CP than controls
- 48%
HR-pQCT parameters at metaphyseal radius
- Similar between groups
Original publication
Ambulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture. J Bone Miner Res. Published 10 February 2025. doi:10.
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