The definition of atypical femoral fractures should include periprosthetic femoral fractures (periprosthetic AFFs (PAFFs))
Authors' conclusion
Periprosthetic hip fractures may rarely have features of AFFs. Fracture nonunion may complicate PAFFs.
Study context
- Population
- Veterans (age ≥ 50) in the VA Corporate Data Warehouse with ≥1 filled prescription for oral or IV BP or denosumab (October 1999–December 2022) before an ICD code for periprosthetic hip fracture
- Participants
- 76 periprosthetic hip fractures
- Outcome
- Prodromal symptoms, frequency, treatment and outcomes of periprosthetic AFFs (PAFFs)
Methodological detailsradiograph review, medical record review
- Radiograph review
- Medical record review
Main finding
As reported in the abstract
Frequency of PAFF among ICD-coded periprosthetic hip fractures
PAFFs among 76 ICD-coded periprosthetic hip fractures (≈400,000 veterans receiving BP or denosumab)
1
Contralateral atypical femoral fracture (AFF)
0
Observational data: associations, not effects.
Further findings
Treatment and outcome of the PAFF · 12 months following PAFF
- BP discontinued; fracture treated with an interlocking plate with cerclage wires
- Chronic nonunion
Safety
Infectious complications after PAFF treatment · 12 months following PAFF
- No infectious complications
Original publication
The definition of atypical femoral fractures should include periprosthetic femoral fractures (PAFFs). Osteoporos Int. Published 7 February 2025. doi:10. 1007/ s00198-025-07401-8
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