Osteoporosis, bone & mineral

The definition of atypical femoral fractures should include periprosthetic femoral fractures (periprosthetic AFFs (PAFFs))

Osteoporos IntPublished Retrospective cohort study

Authors' conclusion

Periprosthetic hip fractures may rarely have features of AFFs. Fracture nonunion may complicate PAFFs.

Study context

Population
Veterans (age ≥ 50) in the VA Corporate Data Warehouse with ≥1 filled prescription for oral or IV BP or denosumab (October 1999–December 2022) before an ICD code for periprosthetic hip fracture
Participants
76 periprosthetic hip fractures
Outcome
Prodromal symptoms, frequency, treatment and outcomes of periprosthetic AFFs (PAFFs)
Methodological detailsradiograph review, medical record review
  • Radiograph review
  • Medical record review

Main finding

As reported in the abstract

Frequency of PAFF among ICD-coded periprosthetic hip fractures

PAFFs among 76 ICD-coded periprosthetic hip fractures (≈400,000 veterans receiving BP or denosumab)

1

Contralateral atypical femoral fracture (AFF)

0

Observational data: associations, not effects.

Further findings

Treatment and outcome of the PAFF · 12 months following PAFF

BP discontinued; fracture treated with an interlocking plate with cerclage wires
Chronic nonunion

Safety

Infectious complications after PAFF treatment · 12 months following PAFF

No infectious complications

Original publication

The definition of atypical femoral fractures should include periprosthetic femoral fractures (PAFFs). Osteoporos Int. Published 7 February 2025. doi:10.1007/s00198-025-07401-8

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