Mortality following atypical femoral fractures in men
Authors' conclusion
It is possible that mortality is lower following AFF compared with a hip or ST/FS fracture; however, limited sample size among those with AFF may have precluded ascertainment of such a difference.
Study context
- Population
- Men from the Veterans Affairs Corporate Data Warehouse who filled ≥1 bisphosphonate (BP) prescription (October 1, 1999, to December 31, 2022) and had a fracture after a first filled BP prescription
- Exposure
- AFF vs hip fracture vs typical ST/FS fracture
- Outcome
- Mortality following fracture
- Follow-up
- 5 yrs
Main finding
As reported in the abstract
P = 0.045
- Cox proportional hazard models, with and without adjustment for covariates: no significant differences in mortality following an AFF vs a hip fracture or an AFF vs a ST/FS fracture
- P > 0.10 for all
Observational data: associations, not effects.
Further findings
Mortality · 12-mo post-fracture
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mortality following atypical femoral fractures in men. J Bone Miner Res. Published 23 February 2026. doi:10.
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