Brief, Low-impact, High-intensity Osteogenic Loading in Postmenopausal Osteoporosis: A Quasi-experimental Case-series Study
An erratum to this article was published (J Clin Endocrinol Metab, 7 Aug 2025 ↗)
Authors' conclusion
The Osteostrong® intervention showed modest lumbar spine BMD improvements over 12 months; some subgroup effects were significant but not when Bonferroni-adjusted, warranting cautious interpretation and further randomized trials.
Study context
- Population
- Peri-/postmenopausal women with osteoporosis; group A (Osteostrong®, n=75) and group B (no Osteostrong®, n=72)
- Participants
- 147 women
- Comparison
- Osteostrong® vs no Osteostrong®
- Outcome
- Changes in BMD and TBS in the lumbar spine and/or hip
- Follow-up
- 12 months
Methodological detailsBonferroni-adjusted non-parametric paired tests
- Bonferroni-adjusted non-parametric paired tests
Main finding
As reported in the abstract
Lumbar spine BMD, mean paired change (within-subgroup)
| Group | Value | Bonferroni-adjusted p |
|---|---|---|
| G2 | mean 0.029 g/cm² | p < 0.001 |
| G4 | mean 0.025 g/cm² | p = 0.05 |
Value
G2mean 0.029 g/cm²
G4mean 0.025 g/cm²
Bonferroni-adjusted p
G2p < 0.001
G4p = 0.05
Further findings
| Outcome | G2 |
|---|---|
| Total hip left BMD, mean paired change (within-subgroup) · 12 months | mean 0.028 g/cm² |
| Bonferroni-adjusted p | p = 0.05 |
Other within-group changes (femoral neck bone mineral density (BMD), total hip BMD, trabecular bone score (TBS)) · 12 months
- Did not retain significance after Bonferroni correction
Original publication
Brief, Low-impact, High-intensity Osteogenic Loading in Postmenopausal Osteoporosis: A Quasi-experimental Case-series Study. J Clin Endocrinol Metab. Published 7 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →