Distinguishing risk of curve progression in adolescent idiopathic scoliosis with bone microarchitecture phenotyping: a 6-year longitudinal study
Main finding · Curve progression to surgical threshold at skeletal maturityResult — go to the resultOdds ratio 4.88 95% CI 1.03–28.63Authors' conclusion
In conclusion, 3 distinct bone microarchitecture phenotypes could be clustered by unsupervised machine learning on HR-pQCT-generated bone parameters at peripubertal PHV in AIS. The bone quality reflected by these phenotypes was found to have significant differentiating risk of curve progression and progression to surgical threshold at skeletal maturity in AIS.
Study context
- Population
- Girls with adolescent idiopathic scoliosis (AIS); phenotypes clustered on high-resolution peripheral quantitative computed tomography (HR-pQCT) parameters at peripubertal peak height velocity (PHV)primary cohort
- Participants
- 101 participants
- Exposure
- Bone microarchitecture phenotypes 2 and 3 vs phenotype 1
- Outcome
- Curve progression and progression to surgical threshold at skeletal maturity (primary cohort)
- Follow-up
- Skeletal maturity; 6.22 ± 0.33 years
Methodological detailsunsupervised machine learning clustering (fuzzy C-means), 6-year follow-up
- Unsupervised machine learning clustering (fuzzy C-means)
- 6-year follow-up
Main finding
As reported in the abstract
Curve progression to surgical threshold at skeletal maturity
Odds ratio
4.88
95% CI 1.03–28.63
Phenotype 3vs Phenotype 1
OR 4.88 (95% CI 1.03–28.63)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted OR (95% CI) | |
|---|---|---|
| Curve progression ≥6° (secondary cohort, mild AIS below bracing threshold, n = 106) · mean follow-up 3.03 ± 0.16 yearsPhenotype 2vs Phenotype 1Reference not stated | 5.39 (1.47–22.76) | |
| Curve progression ≥6° (secondary cohort, mild AIS below bracing threshold, n = 106) · mean follow-up 3.03 ± 0.16 yearsPhenotype 3vs Phenotype 1Reference not stated | 3.67 (1.05–14.29) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Original publication
Distinguishing risk of curve progression in adolescent idiopathic scoliosis with bone microarchitecture phenotyping: a 6-year longitudinal study. J Bone Miner Res. Published 4 June 2024. doi:10.
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