Kidney function in acromegaly: evidence from a long-term observational study
Authors' conclusion
Renal hyperfiltration in acromegaly tends to normalize following treatment, with a more rapid response observed in patients who undergo surgery. Chronic kidney disease is highly prevalent in acromegaly and is closely linked to diabetes, which further contributes to the increased cardiovascular risk seen in these individuals.
Study context
- Population
- Patients with acromegaly followed long-term at a single centre; mean age 43.7 years, 46 male; diabetes 31.25%, hypertension 65%single centre
- Participants
- 80 patients
- Exposure
- Surgery vs exclusively medical therapy
- Surgeryn = 51
- Medical therapyn = 29
- Outcome
- eGFR (CKD-EPI 2021) over time: acute slope (first 12 months after treatment) and chronic slope (long-term follow-up)
- Follow-up
- Mean 11.28 years
Methodological detailssingle-centre, long-term observational
- Single-centre
- Long-term observational
Main finding
As reported in the abstract
Acute estimated glomerular filtration rate (eGFR) decrease after treatment in all groups, more pronounced in surgically treated patients (mean, mL/min/1.73 m²; p = 0.042)
- 15.15
Mean chronic eGFR loss (mL/year)
- 1.28
Age associated with greater eGFR decline (OR per year; p < 0.01)
1.09
Diabetes associated with greater eGFR decline (OR; p < 0.01)
5.66
Observational data: associations, not effects.
Original publication
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