Acromegaly and the risk of cancer: a nationwide population-based cohort study in Korea
Main finding · Overall cancerResult — go to the resultHazard ratio 1.90 95% CI 1.63–2.22Authors' conclusion
This nationwide longitudinal cohort study shows an increased risk of cancer in patients with acromegaly Active and long-term cancer screening is necessary in patients with acromegaly.
Study context
- Population
- Patients with acromegaly and controls aged above 20, Korea, 2006 to 2016
- Participants
- 2,382 vs 11,910
- Exposure
- Acromegaly vs controls
- Acromegalyn = 2,382
- Controlsn = 11,910reference
- Outcome
- Overall and site-specific cancer risk
Methodological detailsnationwide, longitudinal
- Nationwide
- Longitudinal
Main finding
Overall cancer
Hazard ratio
1.90
95% CI 1.63–2.22
Events by group
Acromegalyvs Controls
HR 1.90 (95% CI 1.63–2.22)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Brain cancerHighest relative risk | 6.80 (2.83–16.38) | |
| 0.050.21520Hazard ratio (log scale) |
Other site-specific cancers
- Significantly higher risk of lymphoma, thyroid cancer, multiple myeloma, pancreatic cancer and colorectal cancer with acromegaly
Cancer by follow-up duration · ≥5 years
- Significantly higher cancer incidence persisted even 5 years after acromegaly diagnosis
Cancer by age and sex
- Overall cancer risk, particularly stomach cancer, significantly higher in patients <50 years vs older patients
- No significant difference between sexes
Original publication
Acromegaly and the risk of cancer: a nationwide population-based cohort study in Korea. Eur J Endocrinol. Published 5 March 2025. doi:10.
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