Systematic Review and Meta‐Analysis on the Prevalence of Radiotherapy‐Induced Hypopituitarism in Adults With Primary Non‐Pituitary Brain Tumours
Authors' conclusion
Radiotherapy-induced hypopituitarism is common, affecting almost half of survivors with a primary non-pituitary brain tumour arising in adulthood. Protocolised endocrine surveillance is essential in this cohort to identify and treat pituitary hormone deficits in a timely manner. These patients report decreased quality of life which may be due, in part, to undiagnosed pituitary dysfunction.
Study context
- Population
- Survivors of primary non-pituitary brain tumours arising in adulthood treated with radiotherapy
- Participants
- 580 survivors14 studies
- Outcome
- Pooled prevalence of radiotherapy-induced hypopituitarism (per hormone axis)
Methodological detailsrandom effects meta-analysis, five databases searched, two independent reviewers, meta-regression
- Random effects meta-analysis
- Five databases searched
- Two independent reviewers
- Meta-regression
Pooled result
As reported in the abstract
Pooled prevalence of hypopituitarism
- Hypopituitarism, pooled prevalence
- 48% (95% CI 36.7-59.4; I2 = 81%)
- Growth hormone (GH) deficiency, pooled prevalence
- 35.2% (95% CI 24.2-47.0; I2 = 81.4%)
- Gonadotropin deficiency, pooled prevalence
- 20.9% (95% CI 14.4-28.1; I2 = 63.1%)
- Adrenocorticotrophic hormone (ACTH) deficiency, pooled prevalence
- 16.0% (95% CI 11.4-21.1; I2 = 42.6%)
- Thyroid stimulating hormone (TSH) deficiency, pooled prevalence
- 18.2% (95% CI 12.3-24.8; I2 = 63.5%)
Original publication
Systematic Review and Meta‐Analysis on the Prevalence of Radiotherapy‐Induced Hypopituitarism in Adults With Primary Non‐Pituitary Brain Tumours. Clin Endocrinol (Oxf). Published 24 February 2025. doi:10.
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