Clinical Characteristics and Postoperative Growth in Japanese Children with Craniopharyngioma
Authors' conclusion
Children with CP have distinctive clinical characteristics and postoperative growth patterns. Identifying symptoms using school-based auxological measurements could help in early diagnosis.
Study context
- Population
- Japanese children diagnosed with craniopharyngioma undergoing trans-sphenoidal or trans-cranial surgery, or both, followed up ≥3 years, Toranomon Hospital, Tokyo; median age at diagnosis 9.3 (0.9–18) years; 44 females
- Participants
- 73 children
- Outcome
- Clinical characteristics and postoperative growth
Methodological detailssingle-centre, retrospective analysis of medical records (2000-2022)
- Single-centre
- Retrospective analysis of medical records (2000-2022)
Main finding
As reported in the abstract
- Height SDS at diagnosis
- −1.7 (−4.0 to 1.3)
- Body mass index (BMI) SDS at diagnosis
- 0.21 (−2.3 to 2.2)
- Chief complaint neurologic
- n = 25, 34.2%
- Chief complaint endocrine
- n = 22, 30.1%
- Chief complaint ophthalmic
- n = 22, 30.1%
- Accompanying neurologic symptoms
- 34 (46.6%)
- Accompanying endocrine symptoms
- 63 (86.3%)
- Accompanying ophthalmic symptoms
- 37 (50.7%)
- Growth without GH (growth without growth hormone (GWGH)) 1 year after surgery
- 7 (13%)
- GWGH transient (MRI-evident hypothalamic involvement category)
- n = 3, 5.6%
- GWGH permanent (MRI-evident hypothalamic involvement category)
- n = 4, 7.4%
- Preoperative hydrocephalus, the only factor significantly associated with postoperative GWGH at 1 year
- n = 21, 32.8%; p = 0.037
Observational data: associations, not effects.
Original publication
Clinical Characteristics and Postoperative Growth in Japanese Children with Craniopharyngioma. Clin Endocrinol (Oxf). Published 28 February 2025. doi:10.
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