Postoperative weight gain following endoscopic endonasal surgery for craniopharyngiomas in children and adults: A retrospective cohort study
Authors' conclusion
Retroinfundibular tumor extension and hypothalamic damage are key risk factors for postoperative obesity following EES, whereas aggressive resection itself does not increase the risk. Pediatric patients may develop obesity early and persistently, whereas adults, particularly young adults, are prone to gradual weight gain. Early diagnosis and strategic treatment for high-risk individuals may improve the prognosis for patients with hypothalamic obesity.
Study context
- Population
- Patients undergoing initial endoscopic endonasal surgery (EES) for craniopharyngioma at two academic centers
- Participants
- 72 patients
- Exposure
- Pediatric vs Adult
- Pediatricn = 26
- Adultn = 46
- Outcome
- New or worsened obesity (body mass index (BMI) in adults; BMI SD score in pediatric patients)
- Follow-up
- follow-up
Methodological detailstwo academic centers, multivariate logistic regression
- Two academic centers
- Multivariate logistic regression
Main finding
As reported in the abstract
New or worsened obesity, overall
17 patients
23.6%
Retroinfundibular tumor extension, independently associated (OR)
9.81
p = 0.002
Postoperative hypothalamic damage, independently associated (OR)
7.72
p = 0.016
Observational data: associations, not effects.
Further findings
Age-related patterns of weight change (subgroup analyses)
- A subset of pediatric patients developed early-onset and persistent obesity; adults (particularly young adults) had gradual weight gain
Original publication
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