Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients
Authors' conclusion
As acromegaly patients exhibited an impairment either in nervous and in vascular retinal structure at diagnosis, even in the absence of chiasmal compression, SD-OCT and OCTA may represents potential tools to detect retinal damage in these patients.
Study context
- Population
- Newly diagnosed (naïve) acromegaly patients without chiasmal compression; 8 men, 4 women, mean age 49.1 ± 12.3 years
- Participants
- 12 vs 12
- Comparison
- Naïve acromegaly patients vs healthy controls
- Patientsn = 12
- Controlsn = 12reference
- Outcome
- Retinal nervous and vascular structure (Spectral Domain Optical Coherence Tomography (SD-OCT), Optical Coherence Tomography Angiography (OCTA))
- Follow-up
- At diagnosis
Main finding
As reported in the abstract
- Patients vs Controls: P = 0.001
- Patients vs Controls: P = 0.007
- Patients vs Controls: P < 0.001
- Patients vs Controls: P = 0.009
- Patients vs Controls: P = 0.03
Observational data: associations, not effects.
Further findings
Predictors of ganglion cell complex (GCC) and retinal nerve fiber layers (RNFL) average (regression, patients)
- Adenoma volume: best predictor of GCC
- P < 0.001
- Diagnostic delay: best predictor of RNFL average
- P < 0.001
Vessel density (VD) in radial peripapillary capillary (RPC) by diagnostic delay and fasting glucose (patients)
- Lower VD in RPC with diagnostic delay above 8.5 years (median) vs below
- P = 0.009
- Lower VD in RPC with fasting glucose above 90 mg/dl (median) vs below
- P = 0.04
Original publication
Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients. Pituitary. Published 10 October 2025. doi:10.
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