Diagnostic Utility of Fractional Excretion of Urate, Urinary Phosphate and Brain Natriuretic Peptide in Distinguishing Cerebral/Renal Salt Wasting From SIADH in Neurologically Ill Children: A Systematic Review
Authors' conclusion
Current evidence suggests that FEurate, FEphosphate and NT-proBNP may provide diagnostic clues, but each biomarker has limitations related to assay variability, age-dependent reference ranges, comorbidities and confounding medications. FEurate response to sodium correction appears most useful, though serial measurements are often required.
Study context
- Population
- Hyponatremic children with neurologic conditions (SIADH or C/RSW)2 prospective paediatric cohorts
- Comparison
- FEurate, FEphosphate and NT-proBNP for distinguishing C/RSW from SIADH
- Outcome
- Diagnostic accuracy in distinguishing C/RSW from SIADH
Methodological detailsSystematic reviews appraised with AMSTAR 2, Limited by absence of paediatric-specific cut-off values, Searched PubMed, Embase, Web of Science, Scopus and Cochrane Library, Two reviewers independently assessed eligibility and extracted data
- Systematic reviews appraised with AMSTAR 2
- Limited by absence of paediatric-specific cut-off values
- Searched PubMed, Embase, Web of Science, Scopus and Cochrane Library
- Two reviewers independently assessed eligibility and extracted data
Pooled result
As reported in the abstract
Studies identified
Studies identified
69
Prospective paediatric cohort studies on biomarkers in C/RSW vs SIADH
2
Original publication
Diagnostic Utility of Fractional Excretion of Urate, Urinary Phosphate and Brain Natriuretic Peptide in Distinguishing Cerebral/Renal Salt Wasting From SIADH in Neurologically Ill Children: A Systematic Review. Clin Endocrinol (Oxf). Published 7 October 2025. doi:10.
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