Chloride and Potassium Assessment Is a Helpful Tool for Differential Diagnosis of Thiazide-Associated Hyponatremia
Authors' conclusion
In patients with TAH, assessment of aSID, potassium, and chloride in urine can help identifying patients with volume-depleted TAH requiring fluid substitution vs patients with SIAD-like TAH requiring fluid restriction.
Study context
- Population
- Hospitalized patients with thiazide-associated hyponatremia <125 mmol/L, University Hospital Basel and University Medical Clinic Aarau, Switzerland, June 2011–August 2013; categorized by treatment response as volume-depleted or syndrome of inappropriate antidiuresis (SIAD)-like thiazide-associated hyponatremia (TAH)
- Participants
- 98 patients
- Comparison
- aSID, ChU and FUA for differentiating volume-depleted vs SIAD-like TAH
- Outcome
- Identification of volume-depleted TAH
Methodological detailspost hoc analysis of prospectively collected data, two-centre
- Post hoc analysis of prospectively collected data
- Two-centre
Performance
As reported in the abstract
| Test or model | PPV (aSID > 42 mmol/L) | PPV (ChU < 15 mmol/L) | PPV (FUA < 12%) | NPV (aSID < 39 mmol/L) | NPV (ChU < 15 mmol/L) | NPV (FUA < 12%) |
|---|---|---|---|---|---|---|
| aSID | 79.1% | — not stated in the abstract | — not stated in the abstract | 76.5% | — not stated in the abstract | — not stated in the abstract |
| ChU | — not stated in the abstract | 100% | — not stated in the abstract | — not stated in the abstract | 83.3% | — not stated in the abstract |
| FUA | — not stated in the abstract | — not stated in the abstract | 85.7% | — not stated in the abstract | — not stated in the abstract | 64.3% |
PPV (aSID > 42 mmol/L)
aSID79.1%
ChU— not stated in the abstract
FUA— not stated in the abstract
PPV (ChU < 15 mmol/L)
aSID— not stated in the abstract
ChU100%
FUA— not stated in the abstract
PPV (FUA < 12%)
aSID— not stated in the abstract
ChU— not stated in the abstract
FUA85.7%
NPV (aSID < 39 mmol/L)
aSID76.5%
ChU— not stated in the abstract
FUA— not stated in the abstract
NPV (ChU < 15 mmol/L)
aSID— not stated in the abstract
ChU83.3%
FUA— not stated in the abstract
NPV (FUA < 12%)
aSID— not stated in the abstract
ChU— not stated in the abstract
FUA64.3%
— not stated in the abstract
Original publication
Chloride and Potassium Assessment Is a Helpful Tool for Differential Diagnosis of Thiazide-Associated Hyponatremia. J Clin Endocrinol Metab. Published 11 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →