Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly
Authors' conclusion
AT in active acromegaly is associated with a gene expression profile of fibrosis and inflammation, which may corroborate the hyper-metabolic state and provide a means for identifying novel biomarkers.
Study context
- Population
- Patients with acromegaly; RNA sequencing of paired subcutaneous adipose tissue (SAT) biopsies in 6 patients; serum proteins in a larger cohort6 sequenced · serum proteins in a larger cohort 23
- Comparison
- SAT gene expression in active acromegaly vs after curative surgery
- Outcome
- SAT gene expression before vs after disease control
Methodological detailspaired biopsies before and after disease control, RNA sequencing
- Paired biopsies before and after disease control
- RNA sequencing
Main finding
As reported in the abstract
- Genes significantly differentially expressed (P-adjusted < .05)
- 743
Further findings
| Outcome | P value |
|---|---|
| Serum HTRA1, METRNL, S100A8/A9 and PDGFD · after disease controlSignificantly increased after disease control | P < 0.05 |
Correlation of visceral AT (VAT) with serum proteins
- VAT vs HTRA1 (R)
- 0.73
- VAT vs S100A8/A9 (R)
- 0.55
- P for both
- P < 0.05
Original publication
Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly. Eur J Endocrinol. Published 10 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →