Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review
Authors' conclusion
Outcomes and follow up reported for transsphenoidal surgical resection of pituitary adenoma are heterogenous over the last 30 years. This study highlights the necessity to develop a robust, consensus-based, minimum, core outcome set. The next step is to develop a Delphi survey of essential outcomes, followed by a consensus meeting of interdisciplinary experts. Patient representatives should also be included. An agreed core outcome set will enable homogeneous reporting and meaningful research synthesis, ultimately improving patient care.
Study context
- Population
- Studies (1990–2021, English) reporting outcomes of transsphenoidal surgery for pituitary adenoma; >10 patients (prospective) or >500 patients (retrospective)
- Participants
- 427,659 participants178 studies
- Outcome
- Outcomes and follow-up time points reported after transsphenoidal surgery for pituitary adenoma (reporting heterogeneity)
Methodological detailsPRISMA, protocol registered a priori
- PRISMA
- Protocol registered a priori
Pooled result
As reported in the abstract
Outcome domains reported (studies)
- Surgical complications (most reported)
- n = 116, 65%
- Endocrine
- n = 104, 58%
- Extent of resection
- n = 81, 46%
- Ophthalmic
- n = 66, 37%
- Recurrence
- n = 49, 28%
- Quality of life
- n = 25, 19%
- Nasal
- n = 18, 10%
- Defined follow-up time points: endocrine
- n = 56, 31%
- Defined follow-up time points: extent of resection
- n = 39, 22%
- Defined follow-up time points: recurrence
- n = 28, 17%
- Follow-up at discharge
- n = 9
- Follow-up <30 days
- n = 23
- Follow-up <6 months
- n = 64
- Follow-up <1 year
- n = 23
- Follow-up >1 year
- n = 69
Further pooled results
Adenoma pathologies reported (studies)
- ≥2 pathologies in same study
- 91
- Single pathology
- 53
- GH-secreting
- n = 106
- Non-functioning
- n = 101
- ACTH-secreting
- n = 95
- Pathology not stated
- 27
Original publication
Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review. Pituitary. Published 2 March 2023. doi:10.
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