Assessment of Puberty and Hypothalamic–Pituitary–Gonadal Axis Function After Childhood Brain Tumor Treatment
Authors' conclusion
Tumor type, location, and treatment were the risk main factors for HPGA impairment. Awareness that onset can be delayed is essential to guide information of parents and patients, patient monitoring, and timely hormone replacement therapy.
Study context
- Population
- Patients diagnosed with a primary brain tumor before 18 years of age, treated >5 years earlier, monitored at the pediatric endocrinology unit of Necker Enfants-Malades University Hospital (Paris, France), January 2010–December 2015; pituitary adenoma or untreated glioma excluded
- Participants
- 204 patients
- Outcome
- Hypothalamic-pituitary-gonadal axis (HPGA) function and risk factors for HPGA impairment
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
HPGA impairment by tumor type
- Advanced puberty, suprasellar glioma not treated by radiotherapy
- 65%
- Advanced puberty, suprasellar glioma not treated by radiotherapy, diagnosis before 5 years of age
- 70%
- Gonadal toxicity from medulloblastoma chemotherapy, all patients
- 70%
- Gonadal toxicity from medulloblastoma chemotherapy, younger than 5 years at diagnosis
- 87.5%
- Hypogonadotropic hypogonadism in craniopharyngioma, consistently accompanied by GHD
- 70%
Observational data: associations, not effects.
Original publication
Assessment of Puberty and Hypothalamic–Pituitary–Gonadal Axis Function After Childhood Brain Tumor Treatment. J Clin Endocrinol Metab. Published 22 February 2023. doi:10.
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