Hypothalamic-Pituitary Axis Involvement in Primary Central Nervous System Lymphoma
An erratum to this article was published (J Clin Endocrinol Metab, 16 Sep 2026 ↗)
Authors' conclusion
HPA dysfunction in PCNSL is frequent and often underdiagnosed. Hypothalamic involvement is associated broader hormonal impairment.
Study context
- Population
- Adults with primary central nervous system lymphoma (PCNSL) with documented dysfunction of at least one hormonal axis; preexisting hypopituitarism or lack of endocrine data excluded
- Participants
- 99 cases
- Outcome
- Pattern of hypothalamic-pituitary axis (HPA)-related endocrine dysfunction
Methodological detailsrisk of bias assessed with JBI tools, Search of PubMed, EMBASE, Scopus, Web of Science and gray literature, to February 2025
- Risk of bias assessed with JBI tools
- Search of PubMed, EMBASE, Scopus, Web of Science and gray literature, to February 2025
Pooled result
As reported in the abstract
- Isolated adenohypophyseal involvement
- 46%
- Neurohypophyseal involvement
- 8%
- Combined involvement
- 45%
- Gonadal axis involvement
- 89.7%
- Thyroid axis involvement
- 89.2%
Further pooled results
Combined dysfunction by hypothalamic tumour location
| OR (95% CI) | P value | ||
|---|---|---|---|
| Hypothalamic tumors | 9.47 (3.76–23.86) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Most affected pituitary axes
- Gonadal axis involvement
- 89.7%
- Thyroid axis involvement
- 89.2%
Persistent endocrinopathy
- Persistent endocrinopathy was more frequent in progressive disease
Mortality
- No direct association between endocrine dysfunction and mortality
Original publication
Hypothalamic-Pituitary Axis Involvement in Primary Central Nervous System Lymphoma. J Clin Endocrinol Metab. Published 13 November 2025. doi:10.
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