Management of water and electrolyte disorders post-pituitary adenoma surgery: experience with Tolvaptan 7.5 mg at a tertiary care centre
Authors' conclusion
Tolvaptan 7.5 mg may serve as an effective alternative treatment modality in moderate-to-severe SIAD patients.
Study context
- Population
- Patients with water and electrolyte disorders after pituitary adenoma surgery at a tertiary care centre; median age 30 years, 69.5% female, 62.1% macroadenoma, CD 54.8%
- Participants
- 82 patients
- Outcome
- Frequency of water and electrolyte disorders
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Isolated arginine vasopressin deficiency (AVP-D)
- 40.2%
- Isolated syndrome of inappropriate antidiuresis (SIAD)
- 39%
- Biphasic response
- 18.2%
- Triphasic response
- 1.2%
- Cerebral salt wasting
- 1.2%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Serum sodium with tolvaptan 7.5 mg · 24 hours | Tolvaptan 7.5 mg median 5 (range 2–9) mEq/L · baseline serum sodium at initiation (median) 127 (125-130) mEq/L |
- Serum sodium with tolvaptan 7.5 mg — Doses of oral tolvaptan 7.5 mg given to 13 patients
- 25
- Serum sodium with tolvaptan 7.5 mg — Correlation of correction with baseline sodium
- r=−0.29, p = 0.15
- Serum sodium with tolvaptan 7.5 mg — Trend toward higher correction with later postoperative use
- r = 0.34, p = 0.09
- Serum sodium with tolvaptan 7.5 mg: 24-hour increment
Median onset of AVP-D and SIAD
- AVP-D onset, post-operative day
- 1
- SIAD onset, post-operative day
- 4
- Correlation of day of SIAD onset with its duration
- r=−0.43, 0.002
- Inverse correlation
Safety
Overcorrection (>10 mEq/L/24 h) after tolvaptan
- Overcorrection (> 10 mEq/L/24 h)
- 2 patients (15.3%)
- Osmotic demyelination
- 0
Original publication
Management of water and electrolyte disorders post-pituitary adenoma surgery: experience with Tolvaptan 7.5 mg at a tertiary care centre. Pituitary. Published 28 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →