Crooke Cell Adenoma: Is Its Aggressiveness Overestimated? Evidence From a Single‐Centre Experience
Authors' conclusion
Our findings suggest that CCAs may not be as aggressive as previously assumed with respect to biochemical remission and recurrence rates. Nonetheless, their larger tumour size, higher proliferative index, and increased likelihood of residual disease underscore the importance of careful long-term follow-up. Further multicenter studies are warranted to better characterize the clinical course of CCAs.
Study context
- Population
- Patients diagnosed with Cushing's disease (CD) at a tertiary Pituitary Centre
- Participants
- 21 vs 60
- Exposure
- CCA vs non-CCA CD
- CCAn = 21
- non-CCAn = 60reference
- Outcome
- Remission and recurrence rates
- Follow-up
- 3, 6 and 12 months
Methodological detailssingle-centre, tertiary Pituitary Centre
- Single-centre
- Tertiary Pituitary Centre
Main finding
As reported in the abstract
- Remission and recurrence rates at 3, 6 and 12 months did not differ significantly between groups
- CCA vs non-CCA: P > 0.05 for all
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline ACTH levelsHigher with CCA | P = 0.007 |
| Tumour sizeTended to be larger with CCA | P = 0.055 |
| Ki-67 proliferation indexTended to be higher with CCA | P = 0.05 |
| Residual pituitary lesion on follow-up MRIMore frequent with CCA | P = 0.005 |
Baseline ACTH levels
- Otherwise comparable baseline biochemical profiles
Original publication
Crooke Cell Adenoma: Is Its Aggressiveness Overestimated? Evidence From a Single‐Centre Experience. Clin Endocrinol (Oxf). Published 8 March 2026. doi:10.
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