Reported baseline variables in transsphenoidal surgery for pituitary adenoma over a 30 year period: a systematic review
Authors' conclusion
There is heterogeneity in the reporting of baseline variables in patients undergoing transsphenoidal surgery for pituitary adenoma. This review supports the need to develop a common data element to facilitate meaningful comparative research, trial design, and reduce research inefficiency.
Study context
- Population
- Studies reporting outcomes of transsphenoidal surgery for pituitary adenoma, 1990–2021 (PubMed, Embase); English full texts, >10 patients (prospective), >500 patients (retrospective) or randomised trials
- Participants
- 427,659 participants178 studies
- Outcome
- Trends in reported baseline variables and degree of heterogeneity of reported variables
Methodological detailsprotocol registered a priori, PRISMA
- Protocol registered a priori
- PRISMA
Pooled result
As reported in the abstract
Reported baseline variables
- Studies: retrospective
- 52 (29%)
- Studies: prospective
- 118 (66%)
- Studies: RCTs
- 9 (5%)
- Published in last 10 years
- 71%
- Originated from North America
- 38%
- Age reported
- 165 studies, 93%
- Sex reported
- 164 studies, 92%
- Ethnicity reported
- 24%
- Co-morbidities reported
- 25%
- Endocrine baseline variables
- 60%
- Ophthalmic baseline variables
- 34%
- Nasal baseline variables
- 7%
- Cognitive baseline variables
- 5%
- Preoperative radiological variables described
- 132 studies (74%)
- MRI alone (most utilised imaging modality)
- 67%
- Tumour diameter
- 52 studies, 39%
- Tumour volume
- 28 studies, 21%
- Cavernous sinus invasion
- 53 studies, 40%
- Wilson Hardy grade
- 25 studies, 19%
- Knosp grade
- 36 studies, 27%
Original publication
Reported baseline variables in transsphenoidal surgery for pituitary adenoma over a 30 year period: a systematic review. Pituitary. Published 16 October 2023. doi:10.
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