Overcorrection and undercorrection with fixed dosing of bolus hypertonic saline for symptomatic hyponatremia
Authors' conclusion
Our real-world data suggest that fixed dosing of bolus hypertonic saline may expose patients with low and high body weight to more overcorrection and undercorrection, respectively. Prospective studies are needed to develop and validate individualized dosing models.
Study context
- Population
- Patients treated with ≥1 bolus 100 or 150 mL 3% NaCl for symptomatic hyponatremia, 2017–2021
- Participants
- 180 patients
- Exposure
- Body weight categories with fixed-dose bolus 3% NaCl
- Outcome
- Overcorrection (plasma sodium rise >10 mmol/L/24 h, >18 mmol/L/48 h, or relowering therapy) and undercorrection (rise <5 mmol/L/24 h)
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Overcorrection
32 patients
18%
Undercorrection
52 patients
29%
Observational data: associations, not effects.
Further findings
Plasma sodium · 24 h and 48 h
- Plasma sodium rose from 120 mmol/L to 126.4 mmol/L (24 h) and 130.4 mmol/L (48 h)
Overcorrection in patients without rapidly reversible causes
- Overcorrection still occurred more often in patients ≤60 kg
Original publication
Overcorrection and undercorrection with fixed dosing of bolus hypertonic saline for symptomatic hyponatremia. Eur J Endocrinol. Published 7 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →