The Time of the Hypertonic Saline Infusion Test for the Diagnosis of Arginine Vasopressin (AVP) Deficiency Can Be Shortened With LC-MS/MS
Authors' conclusion
LC-MS/MS demonstrated superior diagnostic accuracy for AVP-D at 90 minutes of HST, indicating that the HST time can be shortened from 120 to 90 minutes by measuring AVP with LC-MS/MS.
Study context
- Population
- 16 patients with AVP deficiency (AVP-D) and 28 controls undergoing hypertonic saline infusion test (HST)16 AVP-D, 28 controls
- Comparison
- LC-MS/MS vs radioimmunoassay (RIA) for plasma AVP measurement during HST
- Outcome
- Diagnostic accuracy (ROC analysis) of regression gradients of serum sodium vs plasma AVP for AVP-D
- Follow-up
- 90 and 120 minutes
Performance
As reported in the abstract
Diagnosis of AVP-D · 90 minutes
| Test or model | AUC | Sensitivity | Specificity |
|---|---|---|---|
| LC-MS/MS | 0.97 (95% CI, 0.83-1.00) | 100% | 96% |
| RIA | 0.93 (95% CI, 0.80-0.98) | 100% | 81% |
AUC
LC-MS/MS0.97 (95% CI, 0.83-1.00)
RIA0.93 (95% CI, 0.80-0.98)
Sensitivity
LC-MS/MS100%
RIA100%
Specificity
LC-MS/MS96%
RIA81%
Further findings
Sensitivity and specificity · 120 minutes
- Sensitivity or specificity did not differ between the 2 methods
Original publication
The Time of the Hypertonic Saline Infusion Test for the Diagnosis of AVP Deficiency Can Be Shortened With LC-MS/MS. J Clin Endocrinol Metab. Published 30 July 2025. doi:10.
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