Long-term depot specific changes in adipose tissue after treatment of acromegaly
Authors' conclusion
Treatment of acromegaly leads to an increase in AT mass in a depot- and sex-specific manner both at short-term and long-term follow-up. Glucose metabolism improves rapidly after disease control and persists.
Study context
- Population
- Patients with active acromegaly, adipose tissue (AT) measured by DXA at diagnosis and after treatment at short-term (median 1.9 years) and long-term (median 5.5 years)at diagnosis
- Participants
- 62 patients
- Outcome
- Depot-specific changes in AT (VAT, SAT, TAT) and android to gynoid ratio by DXA
- Follow-up
- Short-term (median (IQR) 1.9 (1.5-2.3)) and long-term 5.5 (3.9-9.5) years
Methodological detailsmixed model analysis adjusted for age
- Mixed model analysis adjusted for age
Main finding
As reported in the abstract
AT depots after treatment · short-term and long-term
- Despite stable BMI, VAT and A/G ratio increased at both time points; SAT mainly increased at short-term, plateauing afterwards
- P < .05 for all
Observational data: associations, not effects.
Further findings
Sex differences in AT
- VAT higher in men
- P = 0.035
- A/G ratio higher in men
- P < 0.001
- A/G ratio increased more in men than in women
- P = 0.003
Glucose and HbA1c
- Glucose and HbA1c decreased short-term and remained stable at long-term
- P < 0.05
Disease activity and remission · long-term
- Increase in AT depots correlated with decrease of disease activity at long-term
- Remission status had no effect on changes in AT mass during follow-up
Original publication
Long-term depot specific changes in adipose tissue after treatment of acromegaly. Eur J Endocrinol. Published 24 February 2024. doi:10.
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