Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis: a monocentric, open-label, proof-of-concept study—the TREASURE study
Authors' conclusion
Our findings suggest that protein powder increases plasma sodium levels in patients with chronic SIAD through protein-induced ureagenesis and osmotic diuresis. The effects are comparable with oral urea.
Study context
- Population
- Outpatients with chronic Syndrome of Inappropriate Antidiuresis (SIAD), University Hospital of Basel, Switzerland, October 2021–February 2023
- Participants
- 17 vs 10
- Comparison
- Protein supplementation followed by oral urea, each for 7 days
- Proteinn = 17
- Oral urean = 10
- Outcome
- Increase in sodium levels from baseline to end of 7-day protein supplementation
- Follow-up
- 7 days
Methodological detailsopen-label, monocentric
- Open-label
- Monocentric
Main finding
As reported in the abstract
Plasma sodium with protein supplementation
Plasma sodium, baseline to day 7
131 (129-133) to 133 (132-137)
Median increase in plasma sodium, mmol L-1 (P = .01)
3
0–5
Further findings
Plasma urea and urine urea to creatinine ratio with protein · 7 days
- Plasma urea increase, mmol L-1 (P < .01)
- 3 (1.7-4.9)
- Urine urea to creatinine ratio increase, mmol mmol-1 (P < .01)
- 21.2 (6.2-29.1)
Oral urea: plasma sodium, plasma urea and urine urea to creatinine ratio · 7 days
- Plasma sodium, baseline to day 7
- 132 (130-133) to 134 (131-136)
- Median increase in plasma sodium, mmol L-1 (P = .06)
- 2 (1-3)
- Plasma urea increase, mmol L-1 (P < .01)
- 5.8 (2.7-9.2)
- Urine urea to creatinine ratio increase, mmol mmol-1 (P < .01)
- 31.0 (18.7-45.1)
- n = 10
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis: a monocentric, open-label, proof-of-concept study—the TREASURE study. Eur J Endocrinol. Published 4 August 2023. doi:10.
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