The Utility of Copeptin Measurement in Hospitalized Pediatric Patients with SIADH
Authors' conclusion
Copeptin levels correlated with a clinical diagnosis of SIADH in hospitalized pediatric patients, particularly if elevated above 8.0 pmol/L at the time of hyponatremia, and the patient met the Schwartz and Bartter clinical criteria for SIADH. However, in some cases of SIADH, copeptin levels may be in normal range and could be considered inappropriately high for the degree of hyponatremia. </p>.
Study context
- Population
- Hospitalized pediatric patients with hyponatremia, Children's Hospital of Orange County, 2021–2024
- Participants
- 19 patients
- Comparison
- SIADH vs non-SIADH causes of hyponatremia; copeptin as diagnostic test
- Outcome
- Ability of copeptin level to distinguish SIADH from non-SIADH causes of hyponatremia (ROC analysis, optimal threshold)
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Copeptin for differentiating SIADH from non-SIADH hyponatremia
| Test or model | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| Copeptin | 83% | 71% | 83% | 71% |
Copeptin
Sensitivity83%
Specificity71%
PPV83%
NPV71%
Further findings
| Outcome | SIADH | Non-SIADH | P value |
|---|---|---|---|
| Copeptin levelHigher with SIADH · median | 14.3 | 5.7 | P = 0.036 |
| Urine sodium levelHigher with SIADH · average | 135.4 | 68.3 | P = 0.036 |
| Diagnosed with SIADH, copeptin >8.0 pmol/L vs not83.3% vs. 28.6%; higher with copeptin >8.0 pmol/L | P = 0.017 |
- Diagnosed with SIADH, copeptin >8.0 pmol/L vs not: Copeptin >8.0 pmol/L 83.3%
Original publication
The Utility of Copeptin Measurement in Hospitalized Pediatric Patients with SIADH. Horm Res Paediatr. Published 21 June 2025. doi:10.
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