Diagnostic Accuracy of Copeptin in the Differential Diagnosis of Patients With Diabetes Insipidus: A Systematic Review and Meta-analysis
Authors' conclusion
Copeptin level measurement is a useful tool for the differential diagnosis of patients with DI and PP. Stimulation before copeptin measurement is necessary in the diagnosis of AVP-D.
Study context
- Population
- Patients with polydipsia-polyuria syndrome; 189 (44.79%) arginine vasopressin deficiency (AVP-D) (cranial DI), 212 (50.24%) primary polydipsia (PP)
- Participants
- 422 patients7 studies
- Comparison
- Stimulated vs baseline copeptin for differential diagnosis of DI and primary polydipsia (PP)
- Outcome
- Diagnostic accuracy of copeptin in differentiating DI from PP
Methodological detailshierarchical summary ROC model, bivariate method, QUADAS-2 quality assessment, Literature search from January 1, 2005, to July 13, 2022
- Hierarchical summary ROC model
- Bivariate method
- QUADAS-2 quality assessment
- Literature search from January 1, 2005, to July 13, 2022
Pooled result
As reported in the abstract
Differentiation of PP vs AVP-D
| Group | Sensitivity | Specificity |
|---|---|---|
| Stimulated copeptin | 0.93 (95% CI, 0.89-0.97) | 0.96 (95% CI, 0.88-1.00) |
Stimulated copeptin
Sensitivity0.93 (95% CI, 0.89-0.97)
Specificity0.96 (95% CI, 0.88-1.00)
Further pooled results
| Outcome | Baseline copeptin |
|---|---|
| Identification of AVP resistance (nephrogenic DI)Pooled estimates | |
| Sensitivity | 1.00 (95% CI, 0.82-1.00) |
| Specificity | 1.00 (95% CI, 0.98-1.00) |
Original publication
Diagnostic Accuracy of Copeptin in the Differential Diagnosis of Patients With Diabetes Insipidus: A Systematic Review and Meta-analysis. Endocr Pract. Published 22 May 2023. doi:10.
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