The Effect and Potential Mechanism Analysis of Growth Hormone–Secreting Pituitary Adenomas on Thyroid Function
Authors' conclusion
The study emphasized the complex interaction between the GH and the thyroid axes in patients with GHPA and highlighted the potential effect of glycemic status and tumor volume on thyroid function.
Study context
- Population
- Patients with growth hormone (GH)-secreting pituitary adenoma (GHPA) first admitted to Beijing Tiantan Hospital, Capital Medical University, 2015–2022
- Participants
- 351 patients
- Outcome
- Relationship between high GH/IGF-1 levels and thyroid function
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Correlations of GH, IGF-1 and IGFBP-3 with thyroid function
- GH negatively correlated with total thyroxine (TT4), free thyroxine (FT4) and thyroid-stimulating hormone (TSH)
- IGF-1 positively correlated with total triiodothyronine (TT3), free triiodothyronine (FT3) and FT4; negatively with TSH
- IGFBP-3 positively correlated with TT3, FT3 and FT3:FT4 ratio
Observational data: associations, not effects.
Further findings
Thyroid function by diabetes mellitus (DM) status
- FT3, TT3, TSH and FT3:FT4 ratio significantly lower in GHPA with DM than GHPA without DM
Thyroid function by tumor volume
- Thyroid function gradually decreased with increasing tumor volume
GH and IGF-1 vs age
- GH and IGF-1 negatively correlated with age
Original publication
The Effect and Potential Mechanism Analysis of Growth Hormone–Secreting Pituitary Adenomas on Thyroid Function. Endocr Pract. Published 20 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →