Outcomes of endoscopic endonasal surgery for pediatric craniopharyngioma with a focus on morphological preservation of the pituitary stalk and endocrine functions
Authors' conclusion
In EES for pediatric craniopharyngiomas, postoperative preservation of some endocrine function is achievable in ID tumors with MPPS. Therefore, preservation of endocrine function should be attempted in cases of ID tumors. However, clinicians should be aware that MPPS increases the risk of tumor recurrence.
Study context
- Population
- Pediatric patients with craniopharyngioma undergoing endoscopic endonasal surgery (EES) with intending preservation of pituitary stalk, 2011–202222 patients
- Participants
- 35 patients
- Exposure
- Group P vs Group ACL
- Group Pn = 25
- Group ACLn = 10reference
- Outcome
- Morphological preservation of the pituitary stalk (MPPS) and postoperative endocrine functional outcomes
Main finding
As reported in the abstract
- Morphological preservation of the pituitary stalk (MPPS) achieved in Group P
- 18 (72%) cases
- Postoperative preservation of some endocrine function in MPPS cases
- 14 (77.8%)
- ID tumor associated with postoperative preservation of some endocrine function
- P < 0.001
- Intraoperative MPPS associated with postoperative preservation of some endocrine function
- P < 0.001
Observational data: associations, not effects.
Further findings
Tumor location
Cases
- ID tumors
- 17
- SD tumors
- 18
- Of 35 EESs
Tumor recurrence (all patients)
- Intraoperative MPPS a significantly associated risk factor for tumor recurrence
- P = 0.044
Original publication
Outcomes of endoscopic endonasal surgery for pediatric craniopharyngioma with a focus on morphological preservation of the pituitary stalk and endocrine functions. Pituitary. Published 5 March 2025. doi:10.
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