Risk factors for postoperative hyponatremia after endoscopic endonasal surgery for nonfunctioning pituitary adenoma
Authors' conclusion
Lower BMI and Esposito grade 3 CSF leakage were independent risk factors for postoperative hyponatremia after EES for nonfunctioning pituitary adenomas/ Pit-NETs. These findings may help identify patients requiring careful postoperative sodium monitoring.
Study context
- Population
- Patients who underwent endoscopic endonasal surgery (EES) for nonfunctioning pituitary adenomas/ pituitary neuroendocrine tumors (Pit-NETs) between April 2014 and March 2024patients retrospectively reviewed
- Participants
- 229 patients
- Outcome
- Postoperative hyponatremia (serum sodium < 135 mEq/L)
Methodological detailsunivariate and multivariate logistic regression analyses
- Univariate and multivariate logistic regression analyses
Main finding
As reported in the abstract
Patients with postoperative hyponatremia
36 patients
15.7%
Mean time of onset after surgery
6.6 ± 1.9 days
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Risk factors for postoperative hyponatremia, multivariate analysisBMI (per unit) | 0.873 (0.778–0.979) | P = 0.021 | |
| 0.512Odds ratio (log scale) |
Risk factors for postoperative hyponatremia, multivariate analysis
| OR (95% CI) | P value | ||
|---|---|---|---|
| Esposito grade 3Independently associated with postoperative hyponatremia | 3.251 (1.006–10.50) | P = 0.049 | |
| 0.050.21520Odds ratio (log scale) |
- Risk factors for postoperative hyponatremia, multivariate analysis: lower body mass index (BMI) independently associated with postoperative hyponatremia
Sodium normalization with fluid restriction alone, among those with postoperative hyponatremia
- Sodium normalization with fluid restriction alone (of the 36 patients with hyponatremia)
- 31 patients (86.1%)
Risk factors for postoperative hyponatremia, univariate analysis
- Lower BMI, Esposito grade 3 cerebrospinal fluid (CSF) leakage, and larger superior-inferior tumor diameter identified as significant risk factors
Original publication
Risk factors for postoperative hyponatremia after endoscopic endonasal surgery for nonfunctioning pituitary adenoma. Pituitary. Published 13 November 2026. doi:10.
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